Preheat your oven to 350°F (175°C) and spray a baking dish with nonstick cooking spray.
In a large bowl, mix together the ground beef, breadcrumbs, eggs, chopped onion, garlic powder, and half of the cheddar cheese until combined.
Shape the mixture into a loaf in the prepared baking dish.
In a small bowl, combine ketchup and Worcestershire sauce; pour half over the meatloaf and reserve the rest.
Bake for approximately 60 minutes or until cooked through.
With 10 minutes left, sprinkle remaining cheddar on top and continue baking until bubbly.
Serve hot with reserved sauce drizzled over.