1. Marinate the chicken: Submerge the chicken breasts in buttermilk for at least 1 hour (or overnight).
2. Prepare dredging station: In a bowl, mix flour, salt, pepper, garlic powder, and cayenne.
3. Dredge the chicken: Remove chicken from buttermilk and coat it thoroughly in the seasoned flour.
4. Heat the oil: In a skillet, heat vegetable oil over medium-high heat until it reaches around 350°F (175°C).
5. Fry the chicken: Carefully add dredged chicken pieces to the oil and fry for 5-7 minutes on each side until golden brown.
6. Drain and serve: Transfer cooked chicken to paper towels to drain excess oil. Enjoy hot with your favorite sides.