Preheat the oven to 350°F (175°C). Grease a loaf pan.

In a mixing bowl, whisk together the flour, baking powder, baking soda, and salt.

In another bowl, cream the softened butter and sugar until light and fluffy.

Add the eggs one at a time, beating well after each addition. Stir in the vanilla extract.

Gradually add the dry ingredients to the wet ingredients, alternating with the buttermilk, mixing until just combined.

Gently fold in the blueberries.

Pour the batter into the prepared loaf pan and smooth the top.

Bake for 50-60 minutes, or until a toothpick inserted into the center comes out clean.

Let the bread cool in the pan for 10 minutes before transferring to a wire rack to cool completely.