Preheat your air fryer to 400°F (200°C).
Pat chicken breasts dry with paper towels.
In a bowl, mix together panko, Parmesan cheese, garlic powder, Italian seasoning, salt, and pepper.
Coat each chicken breast in the breadcrumb mixture, pressing firmly to adhere.
Spray the air fryer basket lightly with cooking spray and place chicken inside without overcrowding. Lightly spray tops again.
Cook for 12-15 minutes or until golden brown and internal temperature reaches 165°F (75°C), flipping halfway through.